does supplementation with royal jelly improve oxidative stress and insulin resistance in type 2 diabetic patients?

background : animal studies have shown antioxidant effects of royal jelly (rj) and its effect on insulin resistance as the most common complication of type 2 diabetes. this study was conducted to determine the effect of rj intake on serum total antioxidant capacity, malondialdehyde and insulin resistance in t2dm. methods : in this randomized controlled trial, forty-six type 2 diabetic patients, aged 25-65 years, with bmi of 20-30 kg/m2, and hba1c of 6-8% were included. the patients were randomly assigned to receive 1000 mg of rj supplement or placebo, 3 times daily for 8 weeks. homa-ir, anthropometric measurements, fasting blood glucose, serum insulin, total antioxidant capacity and malondialdehyde level were measured. results : in comparison with placebo, homa-ir decreased (p=0.015) while serum total antioxidant capacity in-creased significantly in rj group (p=0.016). no significant difference was detected for serum insulin and mda in two groups. conclusions : rj intake may have favorable effects on serum tac and homa-ir in diabetic patients.